CROSSLINKING SUBSTRATE REGULATES FRICTIONAL PROPERTIES OF TISSUE-ENGINEERED CARTILAGE AND CHONDROCYTE RESPONSE TO LOADING

Crosslinking substrate regulates frictional properties of tissue-engineered cartilage and chondrocyte response to loading

Abstract Hydrogels are frequently used in regenerative medicine due to their hydrated, tissue-compatible nature, and tuneable mechanics.While many strategies enable bulk mechanical modulation, little attention is given to tuning surface tribology, and its impact on cellular behavior under mechanical stimuli.Here, we demonstrate that photocrosslinki

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Application of a Dual Optogenetic Silencing-Activation Protocol to Map Motor Neurons Driving Rolling Escape Behavior in Drosophila Larvae

Drosophila larvae exhibit rolling motor behavior as an escape response to avoid predators and painful stimuli.We introduce an accessible method for applying optogenetics to study the motor circuits driving rolling behavior.For this, we simultaneously implement the Gal4-UAS and LexA-Aop binary systems to express two distinct optogenetic channels, Gt

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